Fertilizing a normal (X) egg with this sperm produces an XXY offspring (Klinefelter). [31][50][51][52] However, it is estimated that only 25% of the individuals with Klinefelter syndrome are diagnosed throughout their lives. All content, including text, images, graphics, and information, contained on or available through this website is for general information purposes only. [49], This syndrome, evenly distributed in all ethnic groups, has a prevalence of one to two subjects per every 1000 males in the general population. [18] Gynecomastia is present in about a third of affected individuals, a slightly higher percentage than in the XY population. Tutankhamen was an Egyptian pharaoh of the 18th dynasty who ruled between 1332 BC and 1323 BC. [3][9] Often, symptoms may be subtle and many people do not realize they are affected. [53], The syndrome was named after American endocrinologist Harry Klinefelter, who in 1942 worked with Fuller Albright and E. C. Reifenstein at Massachusetts General Hospital in Boston, Massachusetts, and first described it in the same year. [39], The standard diagnostic method is the analysis of the chromosomes' karyotype on lymphocytes. For nearly 15 years, Bradford Cox has been the frontman of Deerhunter, a band from Atlanta. Troye suffers from a mild form of Marfan syndrome. [1] Symptoms are typically more severe if three or more X chromosomes are present (48,XXXY syndrome or 49,XXXXY syndrome). [40] To investigate the presence of a possible mosaicism, analysis of the karyotype using cells from the oral mucosa is performed. [16] See also Triple X syndrome. People who have KS have an increased risk for autoimmune disorders, like – rheumatoid arthritis, lupus, and Sjogren’s syndrome. [14] Mice can also have the XXY syndrome, making them a useful research model. [3] The primary features are infertility and small poorly functioning testicles. [14] Plunkett and Barr found the sex chromatin body in cell nuclei of the body. Vincent was an actor that had made over 120 television and film appearances. If you have MS, you have a 50:50 chance of passing on the condition to each of your children. Based on pictures and contemporary accounts, he may had Marfan syndrome. [29] XXY males may sit up, crawl, and walk later than other infants; they may also struggle in school, both academically and with sports. In this case, these people actually have 2 X and 1 Y chromosomes. Additional chromosomal material can contribute to cardiac, neurological, orthopedic, and other anomalies. Filed Under: Featured, Medical Articles and Infographics, © 2020 HealthResearchFunding.org - Privacy Policy, 14 Hysterectomy for Fibroids Pros and Cons, 12 Pros and Cons of the Da Vinci Robotic Surgery, 14 Pros and Cons of the Cataract Surgery Multifocal Lens, 11 Pros and Cons of Monovision Cataract Surgery. Troye Sivan started off as a singer in 2006 and in 2008 he released his first original music album. Klinefelter syndrome (47, XXY) is a condition that occurs in men who have an extra X chromosome, resulting in an XXY sex chromosome karyotype. There is usually a small testicle volume of 1–5 ml per testicle (standard values: 12–30 ml). Posted on July 20, 2020  Updated: August 6, 2020 By: Author Health Guide's Editorial. Peter earned a place in cinematic history for his role as Chewbacca in the Star Wars franchise. He was a vocalist for Shleeshiyat Gesher Hayarkon (Yarkon Bridge Trio), Batzal Yarok (Green Onion), and Hahalonot Hagvohim (The High Windows). [28] Also, delays in motor development may occur, which can be addressed through occupational and physical therapies. Also, at the 12th IAAF World Athletic Championships in Berlin, Caster won the 800m race in a best personal time of 1.55.45 seconds. Note – because of the high degree of variability of the syndrome, many of these clinical characteristics can be present at birth or they can manifest later in childhood. Two of the most famous people that suffered from klinefelter syndrome were George Washington artist Lili Elbe. [15], The primary features are infertility and small poorly functioning testicles. An XX egg is produced, which when fertilized with a Y sperm, yields an XXY offspring. Often there is an azoospermia present, rarely an oligospermia. Another mechanism for retaining the extra chromosome is through a nondisjunction event during meiosis II in the egg. Some believe this is because of her Klinefelter syndrome. [22] Despite this misunderstanding of the term, however, XXY men may also have microorchidism (i.e., small testicles). About 10% of XXY males have gynecomastia noticeable enough that they may choose to have cosmetic surgery. I'm only one person, but there are estimates that put the figures between 1 in every 500 males and 1 in every 3000 males. Some of the celebrities include - Michael Phelps and Arik Einstein. He is an American basketball player who played two years of college basketball for Baylor University. Marfan syndrome is an inherited disease that affects the body’s connective tissue, which provides the support, strength, and elasticity to blood vessels, cartilage, heart valves, tendons, and other important parts of the physical body. [21], The term hypogonadism in XXY symptoms is often misinterpreted to mean "small testicles" when it means decreased testicular hormone/endocrine function. Health Guide Net provides qualitative and informative articles on health, diet, and beauty. However, he did not clearly exhibit any of the other clinical features typical of the syndrome. [20] It has been estimated that 50% of males with Klinefelter syndrome can produce sperm. [12] People with the condition have a nearly normal life expectancy. Klinefelter syndrome (KS), also known as 47,XXY is the set of symptoms that result from two or more X chromosomes in males.

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